Publication:
Differential responses of orexigenic neuropeptides to fasting in offspring of obese mothers

dc.contributor.author Chen, Hui en_US
dc.contributor.author Morris, Margaret en_US
dc.date.accessioned 2021-11-25T13:25:12Z
dc.date.available 2021-11-25T13:25:12Z
dc.date.issued 2009 en_US
dc.description.abstract Maternal obesity due to long-term high-fat diet (HFD) consumption leads to faster growth in offspring during suckling, and increased adiposity at 20 days of age. Decreased expression of the orexigenic neuropeptide Y (NPY) and increased anorexigenic proopiomelanocortin (POMC) mRNA expression were observed in the fed state. However, hunger is the major drive to eat and hypothalamic appetite regulators change in response to meals. Therefore it is important to compare both satiated and fasting states. Female Sprague Dawley rats (8 weeks old) were fed a cafeteria-style HFD (15.33kJ/g) or chow for 5 weeks before mating, with the same diet continuing throughout gestation and lactation. At postnatal day 20, male pups were killed either after overnight fasting or in the fed state. Pups from obese dams were hyperphagic during both pre- and post-weaning periods. Pups from obese dams had higher hypothalamic mRNA expression of POMC and NPY Y1 receptor, but lower hypothalamic melanocortin-4 receptor (MC4R) and its downstream target single-minded gene 1 (Sim1), in the fed state. Overnight fasting reduced circulating glucose, insulin, and leptin and increased hypothalamic NPY Y1 receptor mRNA in pups from both lean and obese dams. Hypothalamic NPY and agouti-related protein were only increased by fasting in pups from obese dams; reductions in MC4R and Sim1 were only seen in pups from lean dams. At weaning, the suppressed orexigenic signals in offspring from obese dams were normalized after overnight fasting, while anorexigenic signaling appeared impaired in these animals. This may contribute to their hyperphagia and faster growth. en_US
dc.identifier.uri http://hdl.handle.net/1959.4/42598
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/3.0/au/ en_US
dc.source Legacy MARC en_US
dc.subject.other NPY en_US
dc.subject.other fasting en_US
dc.subject.other obesity en_US
dc.subject.other AgRP en_US
dc.subject.other hyperphagia en_US
dc.title Differential responses of orexigenic neuropeptides to fasting in offspring of obese mothers en_US
dc.type Journal Article en
dcterms.accessRights open access
dspace.entity.type Publication en_US
unsw.accessRights.uri https://purl.org/coar/access_right/c_abf2
unsw.identifier.doiPublisher http://dx.doi.org/10.1038/oby.2009.56 en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 7 en_US
unsw.relation.ispartofjournal Obesity en_US
unsw.relation.ispartofpagefrompageto 1356-1362 en_US
unsw.relation.ispartofvolume 17 en_US
unsw.relation.originalPublicationAffiliation Chen, Hui, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Morris, Margaret, Faculty of Medicine, UNSW en_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ms_Obesity_RV2.doc
Size:
288 KB
Format:
application/msword
Description:
Resource type