Publication:
Effects of deprivation and average ambient solar irradiation on bone health and osteoporosis using the UK biobank cohort study.

dc.contributor.advisor Muscatello, David
dc.contributor.author Mahmud, Mafruha
dc.date.accessioned 2023-08-11T02:31:08Z
dc.date.available 2023-08-11T02:31:08Z
dc.date.issued 2023
dc.date.submitted 2023-07-18T02:47:14Z
dc.description.abstract Osteoporosis is a progressive bone disease characterised by low bone density and micro-architectural deterioration of bone tissue. Socioeconomic deprivation is associated with increased fracture risk. There is, however, a scarcity of, or inconclusive, research on deprivation and total bone health. Thus, in my first study, the role of deprivation on bone health, including low bone density, falls, and fractures was examined. Vitamin D is important for bone health, and humans synthesise it through exposure to solar radiation. Nowadays, although vitamin D supplementation is considered a standard way to effectively treat osteoporosis, it remains unclear whether vitamin D from sunshine has health advantages over supplements. In my second study, the relationship between exposure to average annual ambient ultraviolet B (UVB) radiation across the lifetime, measured by satellite observation, and osteoporosis was investigated. The two studies applied cross-sectional methods to baseline measures from the United Kingdom (UK) Biobank cohort, which includes 502,682 participants aged 40-69 years at recruitment from 2006 through 2010. Univariate and multivariable logistic regression models were built to estimate odds ratios for the associations between exposure and outcome while adjusting for possible confounders. Deprivation was associated with falls (odds ratio for the most deprived quintile compared to the least deprived was 1.46; 95% CI 1.42-1.49), fracture from simple fall (odds ratio for the most deprived category compared to least deprived was 1.16; 95% CI 1.13-1.19), and low bone mineral density (odds ratio for the most deprived quintile compared to least deprived was 1.31; 95% CI 1.26-1.36). The presence of a positive trend towards increasing bone health with declining deprivation suggests a dose-response relationship. No association was found between average lifetime ambient solar UVB radiation and osteoporosis. For osteopenia, only a weak protective association was found between the lowest quantile of UVB and osteopenia. In conclusion, from this large cohort, we found that material deprivation was associated with poor bone health. Using satellite observations of UVB exposure, we did not find evidence of an association between lifetime UVB exposure and the presence of osteoporosis in the UK.
dc.identifier.uri http://hdl.handle.net/1959.4/101401
dc.language English
dc.language.iso en
dc.publisher UNSW, Sydney
dc.rights CC BY 4.0
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject.other Osteoporosis
dc.subject.other Bone Health
dc.subject.other Deprivation
dc.subject.other Ambient solar irradiation
dc.subject.other Falls
dc.subject.other Fracture
dc.title Effects of deprivation and average ambient solar irradiation on bone health and osteoporosis using the UK biobank cohort study.
dc.type Thesis
dcterms.accessRights embargoed access
dcterms.rightsHolder Mahmud, Mafruha
dspace.entity.type Publication
unsw.accessRights.uri http://purl.org/coar/access_right/c_f1cf
unsw.contributor.advisorExternal Rahman, Bayzidur; Australian Institute of Health Innovation, Macquarie University
unsw.contributor.advisorExternal Osborne, Nicholas; School of Public Health, The University of Queensland
unsw.date.embargo 2024-07-09
unsw.date.workflow 2023-07-18
unsw.description.embargoNote Embargoed until 2024-07-09
unsw.identifier.doi https://doi.org/10.26190/unsworks/25108
unsw.isDatasetRelatedToPublication https://www.ukbiobank.ac.uk/enable-your-research/apply-for-access#:~:text=If%20you%20have%20already%20registered,Biobank%20data%2Dfields%20you%20require
unsw.relation.faculty Medicine & Health
unsw.relation.school School of Population Health
unsw.relation.school School of Population Health
unsw.subject.fieldofresearchcode 4202 Epidemiology
unsw.subject.fieldofresearchcode 4206 Public health
unsw.subject.fieldofresearchcode 490502 Biostatistics
unsw.thesis.degreetype Masters Thesis
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