Publication:
Nicotinic transmission at functionally distinct synapses in descending reflex pathways of the rat colon

dc.contributor.author Bian, X.-C. en_US
dc.contributor.author Bornstein, J. C en_US
dc.contributor.author Bertrand, P. P. en_US
dc.date.accessioned 2021-11-25T13:35:05Z
dc.date.available 2021-11-25T13:35:05Z
dc.date.issued 2003 en_US
dc.description.abstract We examined descending reflex pathways in the rat colon using intracellular recording techniques. Inhibitory junction potentials (IJPs) were recorded from circular smooth muscle when descending pathways were excited by combined mucosal compression and distension. IJPs were reduced to 71% of control when synaptic transmission was blocked in the oral stimulation chamber of a divided organ bath suggesting that two reflex pathways exist, the one involving descending sensory neurones and the other involving descending interneurones. Hexamethonium (200 μmol L−1) in the recording chamber abolished reflexly evoked IJPs, while in the stimulation chamber, it was as effective as synaptic blockade. When hexamethonium was added to a chamber lying between the stimulation and recording chambers, it again sharply depressed IJPs to 27% of control; an extent similar to synaptic blockade. A P2 receptor antagonist did not reveal any purinergic neurotransmission. Either granisetron (5-HT3 receptor antagonist, 1 μmol L−1) or SB204070 (5-HT4 receptor antagonist, 1 μmol L−1) in the stimulation chamber significantly decreased IJPs; these decreases were not additive. We conclude that some sensory neurones and interneurones in rat colon have long anally projecting axons and that acetylcholine, acting via nicotinic receptors, is the primary neurotransmitter from sensory neurones, to inhibitory motor neurones and between interneurones. en_US
dc.identifier.issn 1365-2982 en_US
dc.identifier.uri http://hdl.handle.net/1959.4/40036
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/3.0/au/ en_US
dc.source Legacy MARC en_US
dc.title Nicotinic transmission at functionally distinct synapses in descending reflex pathways of the rat colon en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.accessRights.uri http://purl.org/coar/access_right/c_14cb
unsw.identifier.doiPublisher http://dx.doi.org/10.1046/j.1365-2982.2003.00393.x en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofjournal Neurogastroenterology & Motility en_US
unsw.relation.ispartofpagefrompageto 161-171 en_US
unsw.relation.ispartofvolume 15 en_US
unsw.relation.originalPublicationAffiliation Bian, X.-C. en_US
unsw.relation.originalPublicationAffiliation Bornstein, J. C, Medical Sciences, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Bertrand, P. P., Medical Sciences, Faculty of Medicine, UNSW en_US
unsw.relation.school School of Medical Sciences *
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