Publication:
Trophic factors differentiate dopamine neurons vulnerable to Parkinson’s disease

dc.contributor.author Reyes, Stefanie en_US
dc.contributor.author Fu, Yuhong en_US
dc.contributor.author Double, Kay en_US
dc.contributor.author Cottam, Veronica en_US
dc.contributor.author Thompson, Lachlan en_US
dc.contributor.author Kirik, Deniz en_US
dc.contributor.author Paxinos, George en_US
dc.contributor.author Watson, Charles en_US
dc.contributor.author Halliday, Glenda en_US
dc.date.accessioned 2021-11-25T12:29:19Z
dc.date.available 2021-11-25T12:29:19Z
dc.date.issued 2013 en_US
dc.description.abstract Recent studies suggest a variety of factors characterize substantia nigra neurons vulnerable to Parkinson’s disease, including the transcription factors Pitx3 and Otx2 and the trophic factor receptor DCC, but there is limited information on their expression and localisation in adult humans. Pitx3, Otx2 and DCC were immunohistochemically localised in the upper brainstem of adult humans and mice and protein expression assessed using relative intensity measures and online microarray data. Pitx3 was present and highly expressed in most dopamine neurons. Surprisingly, in our elderly subjects no Otx2 immunoreactivity was detected in dopamine neurons, although Otx2 gene expression was found in younger cases. Enhanced DCC gene expression occurred in the substantia nigra, and higher amounts of DCC protein characterised vulnerable ventral nigral dopamine neurons. Our data show that, at the age when Parkinson’s disease typically occurs, there are no significant differences in the expression of transcription factors in brainstem dopamine neurons, but those most vulnerable to Parkinson’s disease rely more on the trophic factor receptor DCC than other brainstem dopamine neurons. en_US
dc.identifier.issn 0197-4580 en_US
dc.identifier.uri http://hdl.handle.net/1959.4/53611
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/3.0/au/ en_US
dc.source Legacy MARC en_US
dc.subject.other dopamine neurons en_US
dc.subject.other deleted in colorectal cancer en_US
dc.subject.other substantia nigra en_US
dc.subject.other orthodenticle homeobox 2 en_US
dc.subject.other Pitx3 en_US
dc.title Trophic factors differentiate dopamine neurons vulnerable to Parkinson’s disease en_US
dc.type Journal Article en
dcterms.accessRights open access
dspace.entity.type Publication en_US
unsw.accessRights.uri https://purl.org/coar/access_right/c_abf2
unsw.description.publisherStatement NOTICE: this is the author’s version of a work that was accepted for publication in Neurobiology of Aging. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neurobiology of Aging, Vol. 34, Issue 3, (2013) DOI 10.1016/j.neurobiolaging.2012.07.019 en_US
unsw.identifier.doiPublisher http://dx.doi.org/10.1016/j.neurobiolaging.2012.07.019 en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 3 en_US
unsw.relation.ispartofjournal Neurobiology of Aging en_US
unsw.relation.ispartofpagefrompageto 873-886 en_US
unsw.relation.ispartofvolume 34 en_US
unsw.relation.originalPublicationAffiliation Reyes, Stefanie, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Fu, Yuhong, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Double, Kay, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Cottam, Veronica, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Thompson, Lachlan, Florey Neuroscience Institutes, Melbourne, Australia en_US
unsw.relation.originalPublicationAffiliation Kirik, Deniz, Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, BMC D11, Lund University, 22184, Lund, Sweden en_US
unsw.relation.originalPublicationAffiliation Paxinos, George, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Watson, Charles, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Halliday, Glenda, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US
unsw.relation.school Neuroscience Research Australia *
unsw.subject.fieldofresearchcode 110903 Central Nervous System en_US
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