Radiotracer studies of the antitumor metallocene molybdocene dichloride with biomolecules Harding, Margaret en_US Campbell, Kate en_US Dillon, Carolyn en_US Smith, S en_US 2021-11-25T13:30:35Z 2021-11-25T13:30:35Z 2007 en_US
dc.description.abstract Neutron irradiation Of Cp2MoCl2 for 24 h afforded the radiotracer (CP2MoCl2)-Mo-99 which was characterised by UV-Vis spectroscopy and thin layer chromatography. Binding experiments with the thiol containing protein human serum albumin (HSA) or calf thymus DNA, were monitored for Mo-99 using a gamma counter. Under the conditions investigated, molar ratios of binding of 0.2:1 (Cp2MoCl2:DNA) and 9.4:1 (Cp2MoCl2:HSA) were calculated. The results are consistent with in vitro coordination studies that have shown strong preferential interaction Of Cp2MoCl2 with thiols versus other donor sites in biomolecules including DNA. (c) 2006 Elsevier Ltd. All rights reserved. en_US
dc.identifier.issn 0277-5387 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.subject.other molybdocene dichloride en_US
dc.subject.other antitumor metallocene en_US
dc.subject.other genotoxicity en_US
dc.subject.other Mo-99-radiotracer en_US
dc.subject.other DNA en_US
dc.subject.other human serum albumin en_US
dc.title Radiotracer studies of the antitumor metallocene molybdocene dichloride with biomolecules en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.identifier.doiPublisher en_US
unsw.relation.faculty Science
unsw.relation.ispartofissue 2 en_US
unsw.relation.ispartofjournal Polyhedron en_US
unsw.relation.ispartofpagefrompageto 456-459 en_US
unsw.relation.ispartofvolume 26 en_US
unsw.relation.originalPublicationAffiliation Harding, Margaret, Chemistry, Faculty of Science, UNSW en_US
unsw.relation.originalPublicationAffiliation Campbell, Kate en_US
unsw.relation.originalPublicationAffiliation Dillon, Carolyn en_US
unsw.relation.originalPublicationAffiliation Smith, S en_US School of Chemistry *
Resource type