Publication:
iHMMune-align: hidden Markov model-based alignment and identification of germline genes in rearranged immunoglobulin gene sequences
iHMMune-align: hidden Markov model-based alignment and identification of germline genes in rearranged immunoglobulin gene sequences
dc.contributor.author | Gaeta, Bruno | en_US |
dc.contributor.author | Malming, Harald R. | en_US |
dc.contributor.author | Jackson, Katherine J.L. | en_US |
dc.contributor.author | Bain, Michael E. | en_US |
dc.contributor.author | Wilson, Patrick | en_US |
dc.contributor.author | Collins, Andrew M. | en_US |
dc.date.accessioned | 2021-11-25T13:23:34Z | |
dc.date.available | 2021-11-25T13:23:34Z | |
dc.date.issued | 2007 | en_US |
dc.description.abstract | Motivation: Immunoglobulin heavy chain (IGH) genes in mature B lymphocytes are the result of recombination of IGHV, IGHD and IGHJ germline genes, followed by somatic mutation. The correct identification of the germline genes that make up a variable VH domain is essential to our understanding of the process of antibody diversity generation as well as to clinical investigations of some leukaemias and lymphomas. Results: We have developed iHMMune-align, an alignment program that uses a hidden Markov model (HMM) to model the processes involved in human IGH gene rearrangement and maturation. The performance of iHMMune-align was compared to that of other immunoglobulin gene alignment utilities using both clonally related and randomly selected IGH sequences. This evaluation suggests that iHMMune-align provides a more accurate identification of component germline genes than other currently available IGH gene characterization programs. | en_US |
dc.identifier.issn | 1367-4803 | en_US |
dc.identifier.uri | http://hdl.handle.net/1959.4/39537 | |
dc.language | English | |
dc.language.iso | EN | en_US |
dc.rights | CC BY-NC-ND 3.0 | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/au/ | en_US |
dc.source | Legacy MARC | en_US |
dc.title | iHMMune-align: hidden Markov model-based alignment and identification of germline genes in rearranged immunoglobulin gene sequences | en_US |
dc.type | Journal Article | en |
dcterms.accessRights | open access | |
dspace.entity.type | Publication | en_US |
unsw.accessRights.uri | https://purl.org/coar/access_right/c_abf2 | |
unsw.description.publisherStatement | This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Bioinformatics following peer review. The definitive publisher-authenticated version [Bioinformatics 2007 23(13):1580-1587] is available online at: http://dx.doi.org/10.1093/bioinformatics/btm147 | en_US |
unsw.identifier.doiPublisher | http://dx.doi.org/10.1093/bioinformatics/btm147 | en_US |
unsw.relation.faculty | Engineering | |
unsw.relation.ispartofissue | 13 | en_US |
unsw.relation.ispartofjournal | Bioinformatics | en_US |
unsw.relation.ispartofpagefrompageto | 1580-1587 | en_US |
unsw.relation.ispartofvolume | 23 | en_US |
unsw.relation.originalPublicationAffiliation | Gaeta, Bruno, Computer Science & Engineering, Faculty of Engineering, UNSW | en_US |
unsw.relation.originalPublicationAffiliation | Malming, Harald R. | en_US |
unsw.relation.originalPublicationAffiliation | Jackson, Katherine J.L. | en_US |
unsw.relation.originalPublicationAffiliation | Bain, Michael E. | en_US |
unsw.relation.originalPublicationAffiliation | Wilson, Patrick | en_US |
unsw.relation.originalPublicationAffiliation | Collins, Andrew M. | en_US |
unsw.relation.school | School of Computer Science and Engineering | * |
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