Lifespan and reproduction in Drosophila: New insights from nutritional geometry Lee, K.P. en_US Simpson, SJ en_US Clissold, F.J. en_US Brooks, R. en_US Ballard, W.O. en_US Taylor, P.W. en_US Soran, N. en_US Raubenheimer, D. en_US 2021-11-25T13:25:17Z 2021-11-25T13:25:17Z 2008 en_US
dc.description.abstract Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. Caloric restriction(CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein–carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. Lifetime egg production, the measure closest to fitness, was maximized at an intermediate P:C ratio of 1:4. Flies offered a choice of complementary foods regulated intake to maximize lifetime egg production. The results indicate a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein. We unite a body of apparently conflicting work within a common framework and provide a platform for studying aging in all organisms. en_US
dc.identifier.issn 1091-6490 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.subject.other Life Histories (incl. Population Ecology) (270706) en_US
dc.subject.other Animal Physiology - Systems (270603) en_US
dc.subject.other Cell Metabolism (270102) en_US
dc.title Lifespan and reproduction in Drosophila: New insights from nutritional geometry en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.description.publisherStatement PNAS is published by the National Academy of Sciences (USA): en_US
unsw.identifier.doiPublisher en_US
unsw.relation.faculty Science
unsw.relation.ispartofissue 7 en_US
unsw.relation.ispartofjournal PNAS en_US
unsw.relation.ispartofpagefrompageto 2498-2503 en_US
unsw.relation.ispartofvolume 105 en_US
unsw.relation.originalPublicationAffiliation Lee, K.P., en_US
unsw.relation.originalPublicationAffiliation Simpson, SJ, en_US
unsw.relation.originalPublicationAffiliation Clissold, F.J., en_US
unsw.relation.originalPublicationAffiliation Brooks, R., Faculty of Science, UNSW en_US
unsw.relation.originalPublicationAffiliation Ballard, W.O., Faculty of Science, UNSW en_US
unsw.relation.originalPublicationAffiliation Taylor, P.W., en_US
unsw.relation.originalPublicationAffiliation Soran, N., en_US
unsw.relation.originalPublicationAffiliation Raubenheimer, D., en_US
Resource type