The erythromycin derivatives, ABT-229 and GM-611, act on motilin receptors in the rabbit duodenum Clark, M. J. en_US Wright, T. en_US Bertrand, P. P en_US Bornstein, J. C. en_US Jenkinson, K. M. en_US Verlinden, M. en_US Furness, J. B. en_US 2021-11-25T13:35:34Z 2021-11-25T13:35:34Z 1999 en_US
dc.description.abstract 1. The present study was undertaken to determine whether the macrolide antibiotic erythromycin, its stable motilide derivatives ABT 229 and GM 611 and motilin act at the same receptors on intestinal muscle 2. Each compound contracted the longitudinal muscle of the rabbit duodenum in a concentration-dependent manner that was unaffected by 1 mumol/L tetrodotoxin. The potency order (pEC50 values in brackets) was motilin (8.4), ABT 229 (7.6), GM 611 (7.5) and erythromycin (6.0). 3. The motilin receptor antagonists GM 109 and [phe3, leu13]-motilin, both shifted the concentration-response curves for each agonist to the right, but did not affect concentration-response relationships for the muscarinic agonist carbachol. Schild regression analysis yielded similar pA2 values for GM 109 (in the range 7.2-7.5) for all agonists. This analysis was not done for [phe3, leu13]motilin, which was a non-competitive antagonist and partial agonist. 4. It is concluded that erythromycin, the motilides and motilin act at the same (motilin) receptor on rabbit duodenal muscle and do not have any detectable actions at other receptors in this preparation. en_US
dc.identifier.issn 0305-1870 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.title The erythromycin derivatives, ABT-229 and GM-611, act on motilin receptors in the rabbit duodenum en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.identifier.doiPublisher en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofjournal Clinical and Experimental Pharmacology and Physiology en_US
unsw.relation.ispartofpagefrompageto 242-245 en_US
unsw.relation.ispartofvolume 26 en_US
unsw.relation.originalPublicationAffiliation Clark, M. J. en_US
unsw.relation.originalPublicationAffiliation Wright, T. en_US
unsw.relation.originalPublicationAffiliation Bertrand, P. P, Medical Sciences, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Bornstein, J. C. en_US
unsw.relation.originalPublicationAffiliation Jenkinson, K. M. en_US
unsw.relation.originalPublicationAffiliation Verlinden, M. en_US
unsw.relation.originalPublicationAffiliation Furness, J. B. en_US School of Medical Sciences *
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