Unlocking the secrets of LRRK2 function with selective kinase inhibitors Dzamko, Nicolas en_US Halliday, Glenda en_US 2021-11-25T12:29:24Z 2021-11-25T12:29:24Z 2013 en_US
dc.description.abstract Leucine rich repeat kinase 2 is currently considered a potential therapeutic target for the treatment of Parkinson’s disease. A number of pathological mutations, all of which lie in the dual catalytic domains of LRRK2, segregate with Parkinson’s disease in an autosomal dominant fashion. The most common mutation, G2019S, results in an increase in the kinase activity of LRRK2 and much work has therefore gone into the development of potent and specific inhibitors of LRRK2 kinase activity. A number of LRRK2 kinase inhibitors have now been employed in the search for the physiological function of LRRK2 and the targets of LRRK2 kinase activity. en_US
dc.identifier.issn 1479-6708 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.subject.other LRRK2-IN1 en_US
dc.subject.other Parkinson’s disease en_US
dc.subject.other kinase en_US
dc.subject.other CZC25146 en_US
dc.subject.other TLR en_US
dc.subject.other WNT en_US
dc.subject.other mitochondria en_US
dc.subject.other neurodegeneration en_US
dc.subject.other endocytosis en_US
dc.subject.other inflammation en_US
dc.title Unlocking the secrets of LRRK2 function with selective kinase inhibitors en_US
dc.type Journal Article en
dcterms.accessRights open access
dspace.entity.type Publication en_US
unsw.identifier.doiPublisher en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 3 en_US
unsw.relation.ispartofjournal Future Neurology en_US
unsw.relation.ispartofpagefrompageto 347-357 en_US
unsw.relation.ispartofvolume 8 en_US
unsw.relation.originalPublicationAffiliation Dzamko, Nicolas, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Halliday, Glenda, Neuroscience Research Australia, Faculty of Medicine, UNSW en_US Neuroscience Research Australia *
unsw.subject.fieldofresearchcode 110903 Central Nervous System en_US
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