Publication:
Non-invasive measures of neural respiratory drive in children: the utility of respiratory muscle electromyography

dc.contributor.advisor Jaffe, Adam en_US
dc.contributor.advisor Teng, Arthur en_US
dc.contributor.author Chuang, Sandra en_US
dc.date.accessioned 2022-03-15T08:28:12Z
dc.date.available 2022-03-15T08:28:12Z
dc.date.issued 2019 en_US
dc.description.abstract Background and aims: Surface electromyography (sEMG) recording of the inspiratory muscles is a potential non-invasive method of assessing neural respiratory drive (NRD) in children. This thesis explored the application of inspiratory muscle sEMG to assess NRD in healthy children and in children with sleep-disordered breathing. The relationship between sEMG and lung function variables of volume and pressure, and other factors affecting interpretation of sEMG were also evaluated. Method: The reliability of a developed method to quantitatively assess sEMG of the diaphragm (sEMGdi) recorded using a commercial sleep study set up was examined. Surface EMG of the diaphragm recorded from snoring children with and without obstructive sleep apnoea, and also from children with sleep-disordered breathing before and after treatment with pressure support were compared. Inspiratory muscle (scalene, parasternal intercostal, and diaphragm) sEMG recorded from healthy children during tidal breathing and maximal inspiratory ramps were evaluated. Variability in peak inspiratory muscle sEMG recorded during different maximal inspiratory manoeuvres were assessed. Linear mixed models were used to assess factors affecting sEMG magnitude. Results: A reliable method using sEMGdi to assess NRD was developed and demonstrated that NRD was significantly higher in children with obstructive sleep apnoea and increased work of breathing compared to healthy snorers. Provision of positive airway pressure support decreased NRD as reflected by decreased sEMGdi from baseline in children with sleep-disordered breathing. Inspiratory muscle sEMG had a curvilinear/linear relationship with increasing lung volume and pressure. Inspiratory muscle tidal sEMG had a negative linear relationship with age and body mass index (BMI), but not biological sex. Postural changes can affect inspiratory muscle sEMG. Peak sEMG of the inspiratory muscles were recorded from the majority of the children when performing the maximal sniff inhalation manoeuvre. Normalising sEMG to a maximal value abolished the influence of BMI, but not age, on sEMG. Conclusion: Diaphragm sEMG recorded from children with and without sleep-disordered breathing using commercial equipment can be quantitively measured to evaluate NRD. Inspiratory muscle sEMG in children is affected by age and BMI. Future work needs to address standardisation of the methodology in order to translate this application into routine clinical practice. en_US
dc.identifier.uri http://hdl.handle.net/1959.4/65288
dc.language English
dc.language.iso EN en_US
dc.publisher UNSW, Sydney en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/3.0/au/ en_US
dc.subject.other Obstructive sleep apnoea en_US
dc.subject.other Diaphragm en_US
dc.subject.other Electromyography en_US
dc.subject.other Intercostal muscles en_US
dc.title Non-invasive measures of neural respiratory drive in children: the utility of respiratory muscle electromyography en_US
dc.type Thesis en_US
dcterms.accessRights open access
dcterms.rightsHolder Chuang, Sandra
dspace.entity.type Publication en_US
unsw.accessRights.uri https://purl.org/coar/access_right/c_abf2
unsw.date.embargo 2022-03-01 en_US
unsw.description.embargoNote Embargoed until 2022-03-01
unsw.identifier.doi https://doi.org/10.26190/unsworks/2084
unsw.relation.faculty Medicine & Health
unsw.relation.originalPublicationAffiliation Chuang, Sandra, Women's & Children's Health, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Jaffe, Adam, Women's & Children's Health, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Teng, Arthur, Women's & Children's Health, Faculty of Medicine, UNSW en_US
unsw.relation.school School of Women's & Children's Health *
unsw.thesis.degreetype PhD Doctorate en_US
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