Publication:
Body composition and energy metabolism in chronic renal insufficiency

dc.contributor.author O'Sullivan, Anthony en_US
dc.contributor.author Lawson, Jane en_US
dc.contributor.author Chan, Maria en_US
dc.contributor.author Kelly, John en_US
dc.date.accessioned 2021-11-25T14:26:22Z
dc.date.available 2021-11-25T14:26:22Z
dc.date.issued 2002 en_US
dc.description.abstract Malnutrition and wasting are important determinants of morbidity and mortality in patients with chronic renal failure on dialysis. The aim of this study was to determine body composition and energy metabolism in patients with chronic renal insufficiency before dialysis. We compared 15 patients (9 women and 6 men) with chronic renal failure (creatinine, 1.5 to 4.2 mg/dL) with 15 normal subjects pair-matched for sex, age (renal failure versus normal, 71 ± 3 years versus 64 ± 3 years), height (1.61 ± 0.02 m versus 1.64 ± 0.02 m), and weight (64.5 ± 2.7 kg versus 66.4 ± 1.5 kg). Body composition was measured by dual-energy x-ray absorptiometry, and total body water was measured by bioelectrical impedance. Energy metabolism was determined by indirect calorimetry. The average glomerular filtration rate for the patients with chronic renal insufficiency was 23.9 ± 2.6 mL/min/1.73 m2. Lean body mass (41.1 ± 2.0 kg versus 44.5 ± 2.2 kg; P = 0.003) and bone mineral content (2.35 ± 0.11 kg versus 2.72 ± 0.12 kg; P = 0.007) were significantly lower in chronic renal insufficiency; however, fat body mass was the same (19.9 ± 2.1 kg versus 19.1±1.4 kg; P = 0.68). Total body water was similar in renal failure (33.4 ± 1.5 L versus 34.4 ± 1.3 L; P = 0.13). Basal energy expenditure was significantly lower in chronic renal insufficiency (1,085 ± 50 kcal/24 hours versus 1,280 ± 54 kcal/24 hours; P = 0.02), even after adjustment for the differences in lean body mass. Daily caloric intake indicated energy intake was similar in the patients with chronic renal insufficiency and the controls. Patients with a relatively modest degree of chronic renal insufficiency are characterized by reduced lean body mass, bone mineral content, and basal energy expenditure. The determinants of lean body mass in chronic renal insufficiency require further investigation. en_US
dc.identifier.issn 0272-6386 en_US
dc.identifier.uri http://hdl.handle.net/1959.4/42571
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/3.0/au/ en_US
dc.source Legacy MARC en_US
dc.title Body composition and energy metabolism in chronic renal insufficiency en_US
dc.type Journal Article en
dcterms.accessRights open access
dspace.entity.type Publication en_US
unsw.accessRights.uri https://purl.org/coar/access_right/c_abf2
unsw.description.publisherStatement Copyright © 2002 The National Kidney Foundation, Inc. Published by Elsevier Inc. en_US
unsw.identifier.doiPublisher http://dx.doi.org/10.1053/ajkd.2002.30558 en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 2 en_US
unsw.relation.ispartofjournal American Journal of Kidney Diseases en_US
unsw.relation.ispartofpagefrompageto 369-375 en_US
unsw.relation.ispartofvolume 39 en_US
unsw.relation.originalPublicationAffiliation O'Sullivan, Anthony, Clinical School - St George Hospital, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Lawson, Jane, Clinical School - St George Hospital, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Chan, Maria, Clinical School - St George Hospital, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Kelly, John, Clinical School - St George Hospital, Faculty of Medicine, UNSW en_US
unsw.relation.school Clinical School St George Hospital *
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