Electrical mapping of the projections of intrinsic primary afferent neurons to the mucosa of the guinea-pig small intestine Bertrand, P. P en_US Kunze, W. A. en_US Bornstein, J. C. en_US Furness, J. B. en_US 2021-11-25T13:34:36Z 2021-11-25T13:34:36Z 1998 en_US
dc.description.abstract The patterns of innervation of the mucosa by axons of individual primary afferent neurons with cell bodies in the myenteric plexus were studied by mapping sites from which electrical stimulation of the mucosa elicited action potentials (APs) in their cell bodies. Segments of guinea-pig ileum were dissected to reveal the myenteric plexus over half of the intestinal circumference, leaving the mucosa intact over the other half. Intracellular recordings were taken from myenteric neurons located within 1 mm of the intact mucosa. Focal electrical stimuli were applied to the mucosa at multiple locations separated by about 1 mm. Neurons that responded had round or oval cell bodies with several long processes (Dogiel type II) and APs that had an inflection on the falling phase (AH-neurons). Responses consisted of single APs or bursts of APs. Maps of the mucosal projections of 30 neurons were generated. The maximum distances from which individual neurons responded were 7 mm circumferential and 2 mm oral or anal to the cell body with a higher proportion of responses from the oral regions. The areas of intact mucosa calculated to be innervated ranged from 1 mm2 up to approximately 15 mm2 (mean 3.9 mm2; median 2.5 mm2). It is estimated that the areas innervated would be two to three times larger under conditions where part of the mucosa is not removed. Some neurons also responded to a chemical or a mechanical stimulus applied to the mucosa within the electrically mapped area. It is concluded that intrinsic primary afferent neurons have overlapping receptive fields with 230 to 350 neurons innervating the same region of mucosa. en_US
dc.identifier.issn 1365-2982 en_US
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri en_US
dc.source Legacy MARC en_US
dc.subject.other Mechanism en_US
dc.title Electrical mapping of the projections of intrinsic primary afferent neurons to the mucosa of the guinea-pig small intestine en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.identifier.doiPublisher en_US
unsw.relation.faculty Medicine & Health
unsw.relation.ispartofissue 6 en_US
unsw.relation.ispartofjournal Neurogastroenterology & Motility en_US
unsw.relation.ispartofpagefrompageto 533-541 en_US
unsw.relation.ispartofvolume 10 en_US
unsw.relation.originalPublicationAffiliation Bertrand, P. P, Medical Sciences, Faculty of Medicine, UNSW en_US
unsw.relation.originalPublicationAffiliation Kunze, W. A. en_US
unsw.relation.originalPublicationAffiliation Bornstein, J. C. en_US
unsw.relation.originalPublicationAffiliation Furness, J. B. en_US School of Medical Sciences *
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