Genotoxicity and Transmission Electron Microscopy of Molybdocene Dichloride

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Abstract
The cytotoxic effects of molybdocene dichloride (Cp2MoCl2) were investigated in V79 Chinese hamster lung cells using the micronucleus assay. Cp2MoCl2 produced significant genotoxic damage whereby 0.2 micronuclei/1000 binucleated cells were induced per μM of Cp2MoCl2. Transmission electron microscopic analysis of thin-sectioned cells treated with Cp2MoCl2 (300 μM) showed distinct morphological alterations of the nuclei, condensation of chromatin, and a high incidence of polynucleated cells. Implications for the mechanism of antitumor action of molybdocene dichloride are discussed.
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Author(s)
Dillon, Carolyn
Harding, Margaret
Campbell, Kate
Foster, Amalanie
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Publication Year
2006
Resource Type
Journal Article
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UNSW Faculty