The use of functional genomics for the identification of the gene cluster encoding for the biosynthesis of the antifungal tambjamine in the marine bacterium Pseudoalteromonas tunicata

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Abstract
A large insert library was created in Escherichia coli from the DNA of the surface-associated marine bacterium Pseudoalteromonas tunicata. Screening of the library for antifungal activity resulted in the detection and identification of a large gene cluster encoding for the biosynthesis of an antifungal tambjamine. A biosynthetic pathway has been proposed based on analysis and annotation of the gene cluster.
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Author(s)
Burke, C
Thomas, Torsten
Egan, S
Kjelleberg, S
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Publication Year
2007
Resource Type
Journal Article
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UNSW Faculty