Publication:
Optimal replication of poliovirus within cells

dc.contributor.author Regoes, R en_US
dc.contributor.author Crotty, S en_US
dc.contributor.author Antia, R en_US
dc.contributor.author Tanaka, Mark en_US
dc.date.accessioned 2021-11-25T13:26:33Z
dc.date.available 2021-11-25T13:26:33Z
dc.date.issued 2005 en_US
dc.description.abstract We construct a mathematical model of the within-cell replication of poliovirus, a prototypic RNA virus, and use realistic parameter estimates to describe the increase of copy number of the viral genome. Our initial model is essentially an exponential growth model; we also consider modifications of this model to account for resource utilization. The saturation of viral replication dynamics observed in experimental systems can be explained in terms of heavy resource use by the virus. We then use our models to consider the conditions under which the growth of poliovirus is optimized. Intriguingly, if poliovirus has optimized its replication within cells, the predicted ratio of positive to negative strands is close to what is actually observed. We interpret our findings in terms of the evolution of life-history traits. en_US
dc.identifier.issn 0003-0147 en_US
dc.identifier.uri http://hdl.handle.net/1959.4/39640
dc.language English
dc.language.iso EN en_US
dc.rights CC BY-NC-ND 3.0 en_US
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/3.0/au/ en_US
dc.source Legacy MARC en_US
dc.subject.other poliovirus en_US
dc.subject.other viral replication en_US
dc.subject.other life-history traits en_US
dc.subject.other resource limitation en_US
dc.subject.other evolution en_US
dc.subject.other optimality en_US
dc.title Optimal replication of poliovirus within cells en_US
dc.type Journal Article en
dcterms.accessRights metadata only access
dspace.entity.type Publication en_US
unsw.accessRights.uri http://purl.org/coar/access_right/c_14cb
unsw.identifier.doiPublisher http://dx.doi.org/10.1086/428295 en_US
unsw.relation.faculty Science
unsw.relation.ispartofissue 3 en_US
unsw.relation.ispartofjournal American Naturalist en_US
unsw.relation.ispartofpagefrompageto 364-373 en_US
unsw.relation.ispartofvolume 165 en_US
unsw.relation.originalPublicationAffiliation Regoes, R en_US
unsw.relation.originalPublicationAffiliation Crotty, S en_US
unsw.relation.originalPublicationAffiliation Antia, R en_US
unsw.relation.originalPublicationAffiliation Tanaka, Mark, Biotechnology & Biomolecular Sciences, Faculty of Science, UNSW en_US
unsw.relation.school School of Biotechnology & Biomolecular Sciences *
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