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(2007)Book ChapterThe possible variability of project delay is useful information to understand and mitigate the project delay risk. However, it is not sufficiently considered in the literature concerning effort estimation and simulation in software product line development. In this paper, we propose a project delay simulation model by introducing a random variable to represent the variability of adaptive rework. The model has been validated through stochastic simulations by comparing generated adaptive rework to an actual change effort distribution, and by sensitivity analysis. The result shows that the proposed model is capable of producing reasonable variability of adaptive rework, and consequently, variability of project delay. Analysis of our model indicates that the strength of dependency has a larger impact than the number of residual defects, for the studied simulation settings. However, high levels of adaptive rework variability did not have great impact on overall project delay.
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(2009)Conference PaperThe Membrane Research Environment (MemRE) is a component research infrastructure project of the Advanced Membrane Technologies for Water Treatment Research Cluster, a research project funded by the CSIRO flagship Water for a Healthy Country. The research cluster, a nationally distributed and multidisciplinary group of researchers including computational and physical chemists, physicists, material scientists, and chemical and mechanical engineers, aims to develop novel membrane materials in order to reduce the energy associated with desalination by 40%. Common hurdles in multidisciplinary research projects include: a lack of consolidation of existing information relevant to the research from all the participating fields; an absence of information infrastructure to promote comparison of results; and the need for a common language to better enable project participants to communicate. MemRE has been designed and implemented as a solution to these hurdles, to provide an integrated research development tool and learning environment.
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(2006)ThesisThe transplantation of ex vivo expanded mobilized peripheral blood haematopoietic stem cells (PBSC), in place of unmanipulated cells following high dose chemotherapy, reduces the period of cytopenia associated with the therapy’s hemotoxicity. In this thesis the development and optimization of a preclinical prototype hollow fiber bioreactor (HFBR) for the ex vivo expansion of PBSC is described. Mass transport measurements and model of metabolite profiles demonstrate that Cuprophan and Polyflux are suitable membrane material for high-density cell expansion in a HFBR. Materials selected for the HFBR were found to be non-toxic following a 20-day saline extraction. Growth factor (GF) adsorption to the Polyflux membrane makes it unsuitable for expansion of GF dependent cells. However, the GF retention and minimal adsorption characteristics of the Cuprophan membrane are appropriate for this application. Cell-free medium degrades at 37ºC by an oxygen dependent process generating byproducts that inhibit cell growth. This process is relevant to perfusion bioreactors where the bulk of the medium is maintained at 37ºC and is cell-free. Albumin was shown to slow the degradation process but was itself degraded by shear damage inflicted during recirculation. Treating recirculating medium with dialysis against albumin was shown to be a more effective way to mitigate the effects of degradation and lengthen the functional life of albumin over conventional suspension of albumin in the recirculating medium. The preclinical prototype HFBR utilised dialysis against albumin to expand KG-1a cultures from densities as low as 3.5x10^5 cells/ml up to as high as 2x10^8 cells/ml with expansion rates equivalent to T-flask cultures. This process was then applied to PBSC where the targeted 100-fold expansion was achieved. Process optimization was continued using cord blood (CB) CD34+ cells. Growth factor loading sufficient for PBSC expansion in the HFBR was inadequate for CB expansions due to greater than anticipated CB uptake rates. The cell product from the HFBR contained significantly greater yields of CD34+ cells than attained using T-flask cultures. The HFBR platform is suitable for PBSC expansion and appears promising for CB expansion.
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(2008)Conference PaperThe Membrane Research Environment (MemRE), is a research infrastructure project of the Advanced Membrane Technologies for Water Treatment Research Cluster, a research project funded by the CSIRO flagship Water for a Healthy Country. The research cluster, a nationally distributed and multidisciplinary group of researchers including computational and physical chemists, physicists, material scientists, and chemical and mechanical engineers, aims to develop novel membrane materials in order to reduce the energy associated with desalination by 40%. test