Dataset:
MCO study tumour collection

dc.contributor.other Ward, Robyn en_US
dc.coverage.spatial Sydney, New South Wales en_US
dc.date.accessioned 2021-11-26T10:31:42Z
dc.date.available 2021-11-26T10:31:42Z
dc.date.issued 2011 en_US
dc.description.abstract The MCO study is a prospective collection of tissues and clinicopathological data from over 1500 individuals undergoing curative resection for colorectal cancer from 1994 to 2010.Clinical and pathological data has been collected on all cases, including clinical follow-up to 5 years collected annually. This data is stored in a relational database, along with key genetic data on all cases, including microsatellite instability and CIMP status, mutation analysis for BRAF and KRAS, and immunohistochemical assessment of tumours. Originating source(s): MCO research group, UNSW (1993-2011) en_US
dc.identifier.uri http://hdl.handle.net/1959.4/004_145
dc.language English
dc.language.iso EN en_US
dc.rights CC-BY-NC-ND en_US
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/3.0/ en_US
dc.subject.other Cancer oncology en_US
dc.subject.other Colorectal cancer en_US
dc.subject.other Mutation analysis en_US
dc.subject.other Immunohistochemical assessment en_US
dc.title MCO study tumour collection en_US
dc.type Dataset en_US
dcterms.accessRights metadata only access
dcterms.rights Access to the data is subject to originating data custodian and ethical restrictions. Ethics committee approval and other access conditions apply. en_US
dcterms.rightsHolder University of New South Wales en_US
dspace.entity.type Dataset en_US
unsw.accessRights.uri http://purl.org/coar/access_right/c_14cb
unsw.contributor.corporate Adult Cancer Program, Lowy Cancer Research Centre en_US
unsw.contributor.leadChiefInvestigator Hawkins, Nick en_US
unsw.contributor.researchDataCreator Hawkins, Nick en_US
unsw.coverage.temporalFrom 1994 en_US
unsw.coverage.temporalTo 2010 en_US
unsw.description.contact Access type: Access by request. Contact the Information Officer for more information: info.acp@unsw.edu.au en_US
unsw.description.storageplace Adult Cancer Program, Lowy Cancer Research Centre, Faculty of Medicine, UNSW Australia en_US
unsw.identifier.doi https://doi.org/10.4225/53/5559205bea135 en_US
unsw.isDatasetRelatingToDataset MCO study whole slide image collection
unsw.isPublicationRelatedToDataset RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas. http://dx.doi.org/10.1038/bjc.2014.31 en_US
unsw.isPublicationRelatedToDataset Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution. http://dx.doi.org/10.1158/2159-8290.CD-13-0285 en_US
unsw.isPublicationRelatedToDataset Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations. http://dx.doi.org/10.1038/ajg.2013.292 en_US
unsw.isPublicationRelatedToDataset PIK3CA and PTEN Gene and Exon Mutation-Specific Clinicopathologic and Molecular Associations in Colorectal Cancer. http://dx.doi.org/10.1158/1078-0432.CCR-12-3614 en_US
unsw.isPublicationRelatedToDataset Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct (beta)-catenin signalling thresholds for tumourigenesis. http://dx.doi.org/10.1038/onc.2012.486 en_US
unsw.isPublicationRelatedToDataset SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer. http://dx.doi.org/10.1158/0008-5472.CAN-12-2706 en_US
unsw.isPublicationRelatedToDataset Relative Distribution of Folate Species Is Associated with Global DNA Methylation in Human Colorectal Mucosa. http://dx.doi.org/10.1158/1940-6207.CAPR-11-0577 en_US
unsw.isPublicationRelatedToDataset Mutated in Colorectal Cancer Protein Modulates the NFkB Pathway. http://ar.iiarjournals.org/cgi/content/long/32/1/73 en_US
unsw.isPublicationRelatedToDataset Methylation of the 3p22 region encompassing MLH1 is representative of the CpG island methylator phenotype in colorectal cancer. http://dx.doi.org/10.1038/modpathol.2010.212 en_US
unsw.isPublicationRelatedToDataset Implementation of Novel Pyrosequencing Assays to Screen for Common Mutations of BRAF and KRAS in a Cohort of Sporadic Colorectal Cancers. http://dx.doi.org/10.1097/PDM.0b013e318182af52 en_US
unsw.isPublicationRelatedToDataset MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa. http://dx.doi.org/10.1038/modpathol.2009.130 en_US
unsw.isPublicationRelatedToDataset Epigenetic Inactivation of a Cluster of Genes Flanking MLH1 in Microsatellite-Unstable Colorectal Cancer. http://dx.doi.org/10.1158/0008-5472.CAN-07-0869 en_US
unsw.isPublicationRelatedToDataset The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancer. http://dx.doi.org/10.1038/sj.bjc.6603630 en_US
unsw.isPublicationRelatedToDataset Germline epimutations of APC are not associated with inherited colorectal polyposis. http://dx.doi.org/10.1136/gut.2005.087486 en_US
unsw.isPublicationRelatedToDataset The role of MYH and microsatellite instability in the development of sporadic colorectal cancer. http://dx.doi.org/10.1038/sj.bjc.6603421 en_US
unsw.isPublicationRelatedToDataset Routine testing for mismatch repair deficiency in sporadic colorectal cancer is justified. http://dx.doi.org/10.1002/path.1851 en_US
unsw.isPublicationRelatedToDataset The CpG Island Methylator Phenotype Is Not Associated with a Personal or Family History of Cancer. http://dx.doi.org/10.1158/0008-5472.CAN-03-3978 en_US
unsw.isPublicationRelatedToDataset Adverse Prognostic Effect of Methylation in Colorectal Cancer Is Reversed by Microsatellite Instability. http://dx.doi.org/10.1200/JCO.2003.03.123 en_US
unsw.isPublicationRelatedToDataset CD103+ intraepithelial lymphocytes - unique population in microsatellite unstable sporadic colorectal cancer. http://dx.doi.org/10.1016/S0959-8049(02)00633-0 en_US
unsw.isPublicationRelatedToDataset Inactivation of p16INK4a by CpG hypermethylation is not a frequent event in colorectal cancer. http://dx.doi.org/10.1002/jso.10310 en_US
unsw.isPublicationRelatedToDataset Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum. http://dx.doi.org/10.1073/pnas.0530278100 en_US
unsw.isPublicationRelatedToDataset The Relationship between Hypomethylation and CpG Island Methylation in Colorectal Neoplasia. http://dx.doi.org/10.1016/S0002-9440(10)63932-6 en_US
unsw.isPublicationRelatedToDataset MIC-1 Serum Level and Genotype Associations with Progress and Prognosis of Colorectal Carcinoma. http://clincancerres.aacrjournals.org/content/9/7/2642.long en_US
unsw.isPublicationRelatedToDataset The Role of hMLH1 Methylation in the Development of Synchronous Sporadic Colorectal Carcinomas. http://dx.doi.org/10.1007/s10350-004-6266-1 en_US
unsw.isPublicationRelatedToDataset Low-Level Microsatellite Instability Occurs in Most Colorectal Cancers and Is a Nonrandomly Distributed Quantitative Trait. http://cancerres.aacrjournals.org/content/62/1/53.abstract en_US
unsw.isPublicationRelatedToDataset Microsatellite instability and the clinicopathological features of sporadic colorectal cancer. http://dx.doi.org/10.1136/gut.48.6.821 en_US
unsw.isPublicationRelatedToDataset Sporadic Colorectal Cancers With Microsatellite Instability and Their Possible Origin in Hyperplastic Polyps and Serrated Adenomas. http://dx.doi.org/10.1093/jnci/93.17.1307 en_US
unsw.isPublicationRelatedToDataset Kirsten ras mutations in patients with colorectal cancer: RASCAL II study. http://dx.doi.org/10.1054/bjoc.2001.1964 en_US
unsw.isPublicationRelatedToDataset Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer. http://dx.doi.org/10.1054/bjoc.2000.1554 en_US
unsw.isPublicationRelatedToDataset Factors Influencing the Detection of Mutant K-ras in the Serum of Patients with Colorectal Cancer. http://dx.doi.org/10.1111/j.1749-6632.2000.tb06583.x en_US
unsw.isPublicationRelatedToDataset Clinicopathological significance of erbB-2 expression in colorectal carcinoma. http://dx.doi.org/10.3892/or.6.3.527 en_US
unsw.isPublicationRelatedToDataset Generation of Anti-p53 Fab Fragments from Individuals with Colorectal Cancer Using Phage Display. http://www.jimmunol.org/content/163/4/2276.abstract en_US
unsw.isPublicationRelatedToDataset Coomber DW, Hawkins NJ, Dalley D, Ward RL. (1998) The significance of anti-sialyl-Tn antibodies in patients with colorectal or breast cancer. Neoplasma 45(1):12-16. 1338-4317 (eissn) en_US
unsw.isPublicationRelatedToDataset Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis. http://dx.doi.org/10.1002/(SICI)1097-0142(19970315)79:6%3C1106::AID-CNCR8%3E3.0.CO;2-D en_US
unsw.isPublicationRelatedToDataset Pathological and Genetic Correlates of Apoptosis in the Progression of Colorectal Neoplasia. http://dx.doi.org/10.1159/000218025 en_US
unsw.isPublicationRelatedToDataset Hawkins NJ, Lees J, Ward RL. (1997) Detection of apoptosis in colorectal carcinoma by light microscopy and in-situ end-labelling. Analytical and Quantitative Cytology and Histology 19:227-232. 0884-6812 (issn) https://pubmed.ncbi.nlm.nih.gov/9196805/ en_US
unsw.isPublicationRelatedToDataset Detection of K-ras point mutation by enriched PCR colorimetric plate assay. http://dx.doi.org/10.1006/mcpr.1996.0073 en_US
unsw.isPublicationRelatedToDataset Characterisation and clinicopathological correlates of serum anti-p53 antibodies in breast and colon cancer. http://dx.doi.org/10.1007/BF01209124 en_US
unsw.isPublicationRelatedToDataset A rapid PCR ELISA for the detection of activated K-ras in colorectal cancer. http://dx.doi.org/10.1136/mp.48.5.M273 en_US
unsw.isPublicationRelatedToDataset https://doi.org/10.1053/gast.2002.32997 en_US
unsw.relation.OriginalPublicationAffiliation Adult Cancer Program, Lowy Cancer Research Centre, , Adult Cancer Program, Lowy Cancer Research Centre, en_US
unsw.relation.OriginalPublicationAffiliation Ward, Robyn, Prince of Wales Clin School, Medicine & Health, en_US
unsw.relation.OriginalPublicationAffiliation Hawkins, Nick, School of Medical Sciences, Medicine & Health, en_US
unsw.relation.faculty Medicine & Health
unsw.relation.projectDesc The MCO study is a prospective collection of tissues and clinicopathological data from over 1500 individuals undergoing curative resection for colorectal cancer from 1994 to 2010.Clinical and pathological data has been collected on all cases, including clinical follow-up to 5 years collected annually. This data is stored in a relational database, along with key genetic data on all cases, including microsatellite instability and CIMP status, mutation analysis for BRAF and KRAS, and immunohistochemical assessment of tumours. Originating source(s): MCO research group, UNSW (1993-2011) en_US
unsw.relation.projectTitle Molecular and Cellular Oncology (MCO) Study en_US
unsw.relation.school Clinical School Prince of Wales Hospital
unsw.relation.school School of Medical Sciences
unsw.subject.fieldofresearchcode 111201 Cancer Cell Biology en_US
unsw.subject.fieldofresearchcode 111203 Cancer Genetics en_US
unsw.subject.fieldofresearchcode 111299 Oncology and Carcinogenesis not elsewhere classified en_US
unsw.subject.fieldofresearchcode 111209 Solid Tumours en_US
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